Simple EPR/Alanine Dosimeter for Medical Application
نویسنده
چکیده
Linac x-ray and direct gamma irradiation sources were used in this study to irradiate simple polycrystalline alaninein-glass (AiG) dosimeters with low-doses, typical for medical therapy, and high-doses, typical for syringes’ sterilization processe, respectively. The generated “stable” alanine radicals were quantitatively investigated by electron paramagnetic resonance (EPR) spectroscopy in the presence of an external standard reference (Mn/MgO) to correct for spectrometer sensitivity variation. The results indicated that the de-amination of L-alanine is the main reaction to form the “stable” radical and the AiG-dosimeter gives comparable sensitivity for both low and high radiation doses. Moreover, a linear EPR-radiation dose response is observed over a very wide range, from 0 to 50 kGy, which is contrary to what has been reported by Bruker BioSpin using alanine’s pellet. This linear response and the well-known doses’ cumulative characteristics of alanine are in favor of the use of this simple dosimeter in ample medical applications, particularly the conventional radiotherapy treatment per patient.
منابع مشابه
Development of a Dosimeter for High Doses Assessment Based on Alanine/EPR
INTRODUCTION The increasing use of radiation sources of high activity for industrial and medical applications and in the generation of electric energy and the consequent increase in the probability of to occur accidents, becomes important the research and the development of detectors and dosimetry methods for quality control of the applied doses. The radiation dosimetry is important for all rad...
متن کاملAmmonium dithionate- a new material for highly sensitive EPR dosimetry.
Polycrystalline ammonium dithionate has been examined for its radiation response in the low dose range (<5Gy) using EPR technique. The SO(3)(-) radical ion was detected as a single EPR line with a peak-to-peak derivative width of ca. 0.44mT in irradiated samples and its intensity was found to vary linearly with dose. At equal and moderate settings of microwave power and modulation amplitude amm...
متن کاملAdvancements in accuracy of the alanine dosimetry system. Part 1. The eects of environmental humidity
A one-year study of the EPR signal of g-irradiated (Co) L-a-alanine with simultaneous monitoring of the cavity Q-factor was undertaken. The widespread opinion that the EPR signal remains absolutely stable under normal laboratory storage conditions is inaccurate. At 0% humidity, the signal can be regarded as stable within 21% of its initial value for 6 months for 1 and 10 kGy doses, but for only...
متن کاملLithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
Lithium formate has shown to be a material with properties suitable for electron paramagnetic resonance (EPR) dosimetry, among them up to 7 times higher sensitivity compared to alanine, which is a well-established EPR detector material for dose determinations in radiotherapy. The aim of this thesis was to further investigate the properties of lithium formate and develop the dosimetry system tow...
متن کاملHeavy-ion-induced sucrose radicals investigated using EPR and UV spectroscopy
The potential use of a sucrose dosimeter for estimating both linear energy transfer (LET) and the absorbed dose of heavy ion and X-ray radiation was investigated. The stable free radicals were produced when sucrose was irradiated with heavy ions, such as helium, carbon, silicon and neon ions, and when the X-ray radiation was similar to the obtained electron paramagnetic resonance (EPR) spectra,...
متن کامل